Endocrine Abstracts

Several lines of evidence indicate an increased risk of adverse gestational outcomes in women with Hashimoto’s thyroiditis (HT) already as of TSH levels at early pregnancy >2.5mU/l, and definitely greater for TSH concentration >4mU/l. The latest guidelines recommend preconception TSH levels (pre-C-TSH) in HT women be maintained below 2.5mU/l, this threshold being expected to prevent hypothyroidism occurrence at early gestation.Objectives: To...

Context: Chronic hypercortisolism is known to impact the hypothalamus-pituitary-thyroid (HPT) axis, through a disruption of both thyrotropin-releasing-hormone and thyroid-stimulating hormone (TSH) release. These changes, in turn, are responsible for reduced triiodothyronine (T3) and thyroxine (T4) synthesis and secretion, eventually resulting in central hypothyroidism (C-Hypo). However, data on magnitude and timing of recovery of the above abnormalities are still controversial...

Background: Craniopharingioma patients frequently experience severe obesity, unresponsive to caloric restriction or lifestyle modifications. Recently very-low-ketogenic-diets (VLCKD) proved to be a promising lifestyle intervention for obesity management, but no data are available regarding their effect on hypothalamic obesity (HO).Introduction: We present the outcome of VLCKD protocol applied in young patients with HO following neurosurgery for craniopha...